Questions on Sub Topic-- HW

The main theme that I got from learning about Chief Joseph and the Nez Perce tribe was white supremacy and greed, and the relationships between Native Americans and whites. Which makes me think of the question: how did white self-entitled supremacy effect Native Americans- in their life, culture and original state? It's obvious that whites changed everything of how their original lives were, but how and what did they effect? And then, how did that effect the relationship between people who invaded and those who were invaded?